Hoping that a few French fries, chips, or a store-bought sugary beverage won’t hurt? A groundbreaking Lancet series reveals ultra-processed foods (UPFs) inflict harm on every major human organ, linked to chronic diseases and premature death. These industrially manufactured items, prevalent in diets globally, necessitate urgent policy changes and clear front-of-package labeling to combat their catastrophic health consequences and protect public well-being.